Angiogenesis in multiple sclerosis: is it good, bad or an epiphenomenon?

被引：53

作者：

Kirk, S

Frank, JA

Karlik, S

机构：

[1] Univ Western Ontario, Dept Pathol, London, ON, Canada

[2] Ctr Clin, Lab Diagnost Radiol Res, Expt Neuroimaging Sect, NIH, Bethesda, MD USA

[3] Univ Western Ontario, Dept Diagnost Radiol, London, ON, Canada

[4] Univ Western Ontario, Dept Physiol, London, ON, Canada

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2004年 / 217卷 / 02期

关键词：

angiogenesis; multiple sclerosis; experimental allergic encephalomyelitis; neuroinflammation; VEGF; CNS pathology;

D O I：

10.1016/j.jns.2003.10.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Characteristic pathological features of multiple sclerosis (MS) include inflammation, demyelination and axonal and oligodendrocyte loss. In addition, lesions can also have a significant vascular component. In this review, morphological, biochemical and radiological evidence is presented suggesting angiogenesis as a potential focus for investigation in MS. We hypothesize that angiogenesis plays a significant role in the MS lesion, perpetuating disease progression. Thus, treatment strategies that inhibit angiogenesis may decrease clinical and pathological signs of disease. Several approaches for testing this hypothesis are outlined. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：125 / 130

页数：6

共 75 条

[1] Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases [J].