Dehydroepiandrosterone (DHEA) response to i.v. ACTH in patients with chronic fatigue syndrome

被引：21

作者：

De Becker, P

De Meirleir, K

Joos, E

Campine, I

Van Steenberge, E

Smitz, J

Velkeniers, B

机构：

[1] Free Univ Brussels, MFYS LK Gebouw L, Fac Med & Pharm, B-1050 Brussels, Belgium

[2] Free Univ Brussels, Fac Phys Educ & Phys Therapy, Brussels, Belgium

来源：

HORMONE AND METABOLIC RESEARCH | 1999年 / 31卷 / 01期

关键词：

chronic fatigue syndrome; DHEA; ACTH; hypothalamo-pituitary-adrenal axis;

D O I：

10.1055/s-2007-978690

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies have demonstrated concentrating neuroendocrinological disturbances in chronic fatigue syndrome (CFS) patients, concentrating in particular on low cortisol levels and a hypothalamic deficiency. In order to investigate the dynamic response of the adrenal glands, we measured dehydroepiandrosterone (DHEA) in serum after adreno-corticotropic hormone (ACTH) stimulation during 60 minutes in 22 CFS-patients and 14 healthy controls. We found normal basal DHEA levels, but a blunted serum DHEA response curve to i.v, ACTH injection. This observation adds to the large amount of evidence of endocrinological abnormalities in CFS. Relative glucocorticoid deficiency might contribute to the overall clinical picture in CFS, and could explain some of the immunological disturbances observed in this syndrome.

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页码：18 / 21

页数：4

相关论文

共 30 条

[1] POSSIBLE UP-REGULATION OF HYPOTHALAMIC 5-HYDROXYTRYPTAMINE RECEPTORS IN PATIENTS WITH POSTVIRAL FATIGUE SYNDROME [J].

BAKHEIT, AMO ;

BEHAN, PO ;

DINAN, TG ;

GRAY, CE ;

OKEANE, V .

BRITISH MEDICAL JOURNAL, 1992, 304 (6833) :1010-1012

[2]

BAXTER JD, 1981, ENDOCRINOL METAB, P385

[3] NEUROENDOCRINE RESPONSES TO D-FENFLURAMINE AND INSULIN-INDUCED HYPOGLYCEMIA IN CHRONIC FATIGUE SYNDROME [J].

BEARN, J ;

ALLAIN, T ;

COSKERAN, P ;

MUNRO, N ;

BUTLER, J ;

MCGREGOR, A ;

WESSELY, S .

BIOLOGICAL PSYCHIATRY, 1995, 37 (04) :245-252

[4]

Buchwald D, 1997, J RHEUMATOL, V24, P372

[5] A CHRONIC ILLNESS CHARACTERIZED BY FATIGUE, NEUROLOGIC AND IMMUNOLOGICAL DISORDERS, AND ACTIVE HUMAN HERPESVIRUS TYPE-6 INFECTION [J].

BUCHWALD, D ;

CHENEY, PR ;

PETERSON, DL ;

HENRY, B ;

WORMSLEY, SB ;

GEIGER, A ;

ABLASHI, DV ;

SALAHUDDIN, SZ ;

SAXINGER, C ;

BIDDLE, R ;

KIKINIS, R ;

JOLESZ, FA ;

FOLKS, T ;

BALACHANDRAN, N ;

PETER, JB ;

GALLO, RC ;

KOMAROFF, AL .

ANNALS OF INTERNAL MEDICINE, 1992, 116 (02) :103-113

[6] CONTRASTING NEUROENDOCRINE RESPONSES IN DEPRESSION AND CHRONIC FATIGUE SYNDROME [J].

CLEARE, AJ ;

BEARN, J ;

ALLAIN, T ;

MCGREGOR, A ;

WESSELY, S ;

MURRAY, RM ;

OKEANE, V .

JOURNAL OF AFFECTIVE DISORDERS, 1995, 34 (04) :283-289

[7] STEROIDS AS REGULATORS OF THE MAMMALIAN IMMUNE-RESPONSE [J].

DAYNES, RA ;

ARANEO, BA ;

HENNEBOLD, J ;

ENIOUTINA, E ;

MU, HH .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (01) :S14-S19

[8] RETROVIRAL SEQUENCES RELATED TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-II IN PATIENTS WITH CHRONIC FATIGUE IMMUNE DYSFUNCTION SYNDROME [J].

DEFREITAS, E ;

HILLIARD, B ;

CHENEY, PR ;

BELL, DS ;

KIGGUNDU, E ;

SANKEY, D ;

WROBLEWSKA, Z ;

PALLADINO, M ;

WOODWARD, JP ;

KOPROWSKI, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2922-2926

[9] EVIDENCE FOR IMPAIRED ACTIVATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN PATIENTS WITH CHRONIC FATIGUE SYNDROME [J].

DEMITRACK, MA ;

DALE, JK ;

STRAUS, SE ;

LAUE, L ;

LISTWAK, SJ ;

KRUESI, MJP ;

CHROUSOS, GP ;

GOLD, PW .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 73 (06) :1224-1234

[10]

DEMITRACK MA, 1994, CHRONIC FATIGUE SYND, P285