A novel approach to the indoloquinoline alkaloids cryptotackieine and cryptosanguinolentine by application of cyclization of o-vinylsubstituted arylheterocumulenes

被引：73

作者：

Fresneda, PM ^{[1
]}

Molina, P ^{[1
]}

Delgado, S ^{[1
]}

机构：

[1] Univ Murcia, Fac Quim, Dept Quim Organ, E-30071 Murcia, Spain

来源：

TETRAHEDRON | 2001年 / 57卷 / 29期

关键词：

alkaloids; aza-Wittig reaction; microwave heating; insertion reaction; nitrogen heterocycles;

D O I：

10.1016/S0040-4020(01)00597-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Methyl-3-(o-azidophenyl)quinoline-2-one prepared by cyclization of the corresponding o-vinylsubstituted isocyanate under microwave irradiation is directly converted into cryptotackieine 1 by an intramolecular aza-Wittig reaction with trimethylphosphine; alternatively heating followed by reduction of the resulting indoloquinoline derivative provided cryptosanguinolentine 2. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6197 / 6202

页数：6

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