Synthesis of a nitrogen analogue of salacinol and its α-glucosidase inhibitory activity

被引：42

作者：

Muraoka, O

Ying, S

Yoshikai, K

Matsuura, Y

Yamada, E

Minematsu, T

Tanabe, G

Matsuda, H

Yoshikawa, M

机构：

[1] Kinki Univ, Sch Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

[2] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 11期

关键词：

cyclic sulfate; erythritol; salacinol; glycosidase inhibitor; glucosidase inhibitor; azasugar;

D O I：

10.1248/cpb.49.1503

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A nitrogen analogue 4 of the naturally occurring sulfonium ion salacinol (1), a potent alpha -glucosidase inhibitor isolated from the Ayruvedic medicine Salacia reticulata, was synthesized and its inhibitory activity against alpha -glucosidase tested. Substitution of the sulfur atom in I with a nitrogen reduced the activity considerably. The solid-state stereostructure of the related compound (5) was determined on the basis of single crystal X-ray measurement.

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页码：1503 / 1505

页数：3

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