Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients ≤50 years of age

被引：21

作者：

Chao, TH

Li, YH

Chen, JH

Wu, HL

Shi, GY

Tsai, WC

Chen, PS

Liu, PY

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Internal Med, Div Cardiol, Tainan 70428, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Biochem, Tainan 70428, Taiwan

[3] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 70428, Taiwan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2004年 / 93卷 / 02期

关键词：

D O I：

10.1016/j.amjcard.2003.09.039

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI. (C) 2004 by Excerpta Medica, Inc.

引用

页码：204 / 207

页数：4

共 15 条

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Chao TH, 2003, J AM COLL CARDIOL, V41, p381A

[2]

Ireland H, 1997, CIRCULATION, V96, P15

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