Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development

被引:19
作者
Cannazza, G
Chiarugi, A
Parenti, C
Zanoli, P
Baraldi, M
机构
[1] Univ Modena & Reggio Emilia, Dipartimento Sci Farmaceut, I-41100 Modena, Italy
[2] Univ Florence, Dept Preclin & Clin Pharmacol, Florence, Italy
关键词
kynurenic acid; anthranilic acid; quinolinic acid; indoleamine 2,3-dioxygenase;
D O I
10.1023/A:1010960812204
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Kynurenic, anthranilic, and quinolinic acid, brain tissue concentrations and indoleamine 2,3-dioxygenase [EC 1 13.11.17] activity were determined in rat brain, during pre- and postnatal development. Quinolinic acid brain tissue concentration was significantly increased at birth as compared with the prenatal level, then it declined rapidly in the postnatal period. By the contrary, kynurenic and anthranilic acids brain tissue concentrations in rat brain were significantly lower at birth as compared with those found prenatally; then kynurenic acid concentration decreased in the first postnatal week and increased thereafter, while anthranilic acid concentration increased in the first postnatal week and decreased thereafter, Indoleamine 2,3-dioxygenase [EC 1 13.11.17] activity were found unchanged in pre and post natal rat brain. The described opposite changes in quinolinic and kynurenic acids concentrations, occurring in pre- and postnatal period, despite the lack of knowledge on the precise role played by these compounds on the different neurotransmitter systems in the brain, could be involved in brain ontogenetic development.
引用
收藏
页码:511 / 514
页数:4
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