Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

被引：318

作者：

Scheff, SW ^{[1
]}

Price, DA ^{[1
]}

机构：

[1] Univ Kentucky, Coll Med, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

来源：

NEUROBIOLOGY OF AGING | 2003年 / 24卷 / 08期

关键词：

Alzheimer's disease; aging; synapses; synaptophysin; neurodegeneration; cognitive ability; association cortex; HUMAN FRONTAL-CORTEX; POSTERIOR CINGULATE CORTEX; CORONARY-ARTERY-DISEASE; QUANTITATIVE ASSESSMENT; HIPPOCAMPAL-FORMATION; ENTORHINAL CORTEX; CEREBRAL-CORTEX; DENTATE GYRUS; PERFORANT PATHWAY; SENILE DEMENTIA;

D O I：

10.1016/j.neurobiolaging.2003.08.002

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Morphologic studies of the neuropathology in Alzheimer's disease (AD) have demonstrated significant loss of synaptic connectivity in many regions of the neocortex and hippocampus. The strongest correlation with cognitive decline in AD is with the synaptic density. This article discusses the ultrastructural studies that have documented changes in synaptic numbers in many areas of association cortex and in the hippocampal dentate gyrus molecular layer. Changes in the synaptic complex are discussed as a possible compensatory mechanism in response to synapse loss and a model is proposed to help relate the significance of these synaptic changes. Comparisons are made between results observed with ultrastructural technique and those utilizing immumohistochemistry to assess changes in synaptic pathology. Possible reasons underlying the synaptic neuropathology are discussed. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1029 / 1046

页数：18

共 107 条

[1] COMPARISON OF SYNAPTIC CHANGES IN THE PRECENTRAL AND POSTCENTRAL CEREBRAL-CORTEX OF AGING HUMANS - A QUANTITATIVE ULTRASTRUCTURAL-STUDY [J].

ADAMS, I .

NEUROBIOLOGY OF AGING, 1987, 8 (03) :203-212

[2] PLASTICITY OF THE SYNAPTIC CONTACT ZONE FOLLOWING LOSS OF SYNAPSES IN THE CEREBRAL-CORTEX OF AGING HUMANS [J].

ADAMS, I .

BRAIN RESEARCH, 1987, 424 (02) :343-351

[3] Hyperphosphorylation induces self-assembly of τ into tangles of paired helical filaments/straight filaments [J].

Alonso, AD ;

Zaidi, T ;

Novak, M ;

Grundke-Iqbal, I ;

Iqbal, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (12) :6923-6928

[4]

Alzheimer A., 1907, Allg Zietschr Psychiatr Psychiatr-Gerichtl Med, V64, P146

[5]

Amaral D.G., 1990, The human Nervous System, P711

[6] DENDRITIC CHANGES IN THE BASAL NUCLEUS OF MEYNERT AND IN THE DIAGONAL BAND NUCLEUS IN ALZHEIMERS-DISEASE - A QUANTITATIVE GOLGI INVESTIGATION [J].

ARENDT, T ;

ZVEGINTSEVA, HG ;

LEONTOVICH, TA .

NEUROSCIENCE, 1986, 19 (04) :1265-1278

[7] The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease [J].

Arnold, Steven E. ;

Hyman, Bradley T. ;

Flory, Jill ;

Damasio, Antonio R. ;

Van Hoesen, Gary W. .

CEREBRAL CORTEX, 1991, 1 (01) :103-116

[8] MORPHOLOGICAL ADAPTIVE RESPONSE OF THE SYNAPTIC JUNCTIONAL ZONES IN THE HUMAN DENTATE GYRUS DURING AGING AND ALZHEIMERS-DISEASE [J].

BERTONIFREDDARI, C ;

FATTORETTI, P ;

CASOLI, T ;

MEIERRUGE, W ;

ULRICH, J .

BRAIN RESEARCH, 1990, 517 (1-2) :69-75

[9] COMPUTER-ASSISTED MORPHOMETRY OF SYNAPTIC PLASTICITY DURING AGING AND DEMENTIA [J].

BERTONIFREDDARI, C ;

FATTORETTI, P ;

MEIERRUGE, W ;

ULRICH, J .

PATHOLOGY RESEARCH AND PRACTICE, 1989, 185 (05) :799-802

[10]

BERTONIFREDDARI C, 1988, SCANNING MICROSCOPY, V2, P1027

← 1 2 3 4 5 6 7 8 9 10 →