Dynamic kinetic resolution

被引：123

作者：

El Gihani, MT ^{[1
]}

Williams, JMJ ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(99)80003-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of transition-metal-enzyme combinations to effect tandem in situ racemisation and resolutions has extended the scope of dynamic kinetic resolutions. This methodology has signalled a more proactive stance to the racemisation process, which has traditionally relied on more fortuitous approaches, namely the exploitation of labile substrates. The development and application of specific racemising enzymes such as mandelate racemase offers potential for future multienzyme dynamic kinetic resolutions.

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页码：11 / 15

页数：5

相关论文

共 19 条

[1] Dynamic kinetic resolution with enzyme and palladium combinations [J].

Allen, JV ;

Williams, JMJ .

TETRAHEDRON LETTERS, 1996, 37 (11) :1859-1862

[2] Synthesis and use of enantiomerically pure tert-leucine [J].

Bommarius, AS ;

Schwarm, M ;

Stingl, K ;

Kottenhahn, M ;

Huthmacher, K ;

Drauz, K .

TETRAHEDRON-ASYMMETRY, 1995, 6 (12) :2851-2888

[3] Dynamic resolutions in asymmetric synthesis [J].

Caddick, S ;

Jenkins, K .

CHEMICAL SOCIETY REVIEWS, 1996, 25 (06) :447-&

[4] Catalytic racemisation of alcohols: Applications to enzymatic resolution reactions [J].

Dinh, PM ;

Howarth, JA ;

Hudnott, AR ;

Williams, JMJ ;

Harris, W .

TETRAHEDRON LETTERS, 1996, 37 (42) :7623-7626

[5] Controlled racemization of optically active organic compounds: Prospects for asymmetric transformation [J].

Ebbers, EJ ;

Ariaans, GJA ;

Houbiers, JPM ;

Bruggink, A ;

Zwanenburg, B .

TETRAHEDRON, 1997, 53 (28) :9417-9476

[6] Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins [J].

Garcia, MJ ;

Azerad, R .

TETRAHEDRON-ASYMMETRY, 1997, 8 (01) :85-92

[7] LIPASE-CATALYZED KINETIC RESOLUTION WITH INSITU RACEMIZATION - ONE-POT SYNTHESIS OF OPTICALLY-ACTIVE CYANOHYDRIN ACETATES FROM ALDEHYDES [J].

INAGAKI, M ;

HIRATAKE, J ;

NISHIOKA, T ;

ODA, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (24) :9360-9361

[8] ONE-POT SYNTHESIS OF OPTICALLY-ACTIVE CYANOHYDRIN ACETATES FROM ALDEHYDES VIA LIPASE-CATALYZED KINETIC RESOLUTION COUPLED WITH INSITU FORMATION AND RACEMIZATION OF CYANOHYDRINS [J].

INAGAKI, M ;

HIRATAKE, J ;

NISHIOKA, T ;

ODA, J .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (21) :5643-5649

[9] Enzymatic resolution of alcohols coupled with ruthenium-catalyzed racemization of the substrate alcohol [J].

Larsson, ALE ;

Persson, BA ;

Backvall, JE .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1997, 36 (11) :1211-1212

[10] STEREOSELECTIVE ORGANIC-SYNTHESIS VIA DYNAMIC KINETIC RESOLUTION [J].

NOYORI, R ;

TOKUNAGA, M ;

KITAMURA, M .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1995, 68 (01) :36-55