Interrelationship of Runx2 and estrogen pathway in skeletal tissues

被引：17

作者：

Jeong, Jae-Hwan ^{[1
]}

Choi, Je-Yong ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, WCU Program, Taegu 700422, South Korea

来源：

BMB REPORTS | 2011年 / 44卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Aromatase; Estrogen pathway; Runx2; OSTEOBLAST-LIKE CELLS; CYP19 AROMATASE GENE; LINE SV-HFO; TRANSCRIPTION FACTOR; CLEIDOCRANIAL DYSPLASIA; RECEPTOR-ALPHA; FAS LIGAND; OSTEOCALCIN GENE; ADIPOSE-TISSUE; BREAST-CANCER;

D O I：

10.5483/BMBRep.2011.44.10.613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Two key molecules in skeletal tissues are bone formation master transcription factor Runx2 and the steroid hormone estrogen. It is well known that these two molecules play pivotal roles in bone homeostasis; however, the functional interaction between Runx2 and estrogen synthesis in skeletal tissues is largely unknown. Recent studies have indicated that there is a positive relationship between Runx2 and the estrogen biosynthesis pathway. In this review, a possible functional link between Runx2 and estrogen synthesis pathway in skeletal tissues will be discusses as well as the biological significance of this interaction. [BMB reports 2011; 44(10): 613-618]

引用

收藏

页码：613 / 618

页数：6

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