Determination of celiprolol and oxprenolol in human plasma by high-performance liquid chromatography and the analytical error function

被引：8

作者：

Braza, AJ ^{[1
]}

Modamio, P ^{[1
]}

Mariño, EL ^{[1
]}

机构：

[1] Univ Barcelona, Fac Pharm, Dept Pharm & Pharmaceut Technol, Clin Pharm & Pharmacotherapy Unit,Hlth Div, E-08028 Barcelona, Spain

来源：

JOURNAL OF CHROMATOGRAPHY B | 1998年 / 718卷 / 02期

关键词：

celiprolol; oxprenolol;

D O I：

10.1016/S0378-4347(98)00378-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Two reversed-phase HPLC methods with UV detection to quantify celiprolol and oxprenolol in human plasma are described. The analytical methods for the determination of both drugs used the same reversed-phase HPLC column, mobile phase and extraction procedure. Linearity was obtained in the ranges 15.63-1008 and 25-800 ng/ml for celiprolol and oxprenolol, respectively. Intra-day and inter-day variation was lower than 144. After validation of the methods, analytical error functions were established as S.D. (ng/ml) = 3.096 + 0.041 C for celiprolol and S.D. (ng/ml)= 8.906 + 8.075.10(-8) C-3 for oxprenolol. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：267 / 272

页数：6

共 22 条

[1]

CASTROCELS M, 1989, ASOCIACION ESPANOLA

[2] ANALYSIS OF OXPRENOLOL IN FORMULATIONS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].