Malabsorption of rifampin and isoniazid in HIV-infected patients with and without tuberculosis

被引：85

作者：

Gurumurthy, P

Ramachandran, G

Kumar, AKH

Rajasekaran, S

Padmapriyadarsini, C

Swaminathan, S

Venkatesan, P

Sekar, L

Kumar, S

Krishnarajasekhar, OR

Paramesh, P

机构：

[1] Indian Council Med Res, Div TB Res Ctr, Madras 600031, Tamil Nadu, India

[2] Govt Hosp Thorac Med, Madras, Tamil Nadu, India

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 38卷 / 02期

关键词：

D O I：

10.1086/380795

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The absorption of rifampin, isoniazid, and D-xylose in patients with human immunodeficiency virus (HIV) infection and diarrhea, in patients with HIV infection and tuberculosis ( TB), in patients with pulmonary TB alone, and in healthy subjects was studied. Percentage of dose of the drugs, their metabolites, and D-xylose excreted in urine were calculated. A significant reduction in the absorption of drugs and D-xylose in both the HIV infection/diarrhea and HIV infection/ TB groups was observed (P<.05), and the correlation between them was significant. Our results indicate that patients with HIV infection and diarrhea and those with HIV infection and TB have malabsorption of rifampin and isoniazid.

引用

页码：280 / 283

页数：4

共 18 条

[1] COMPARATIVE BIOAVAILABILITY OF ISONIAZID, RIFAMPIN, AND PYRAZINAMIDE ADMINISTERED IN FREE COMBINATION AND IN A FIXED TRIPLE FORMULATION DESIGNED FOR DAILY USE IN ANTITUBERCULOSIS CHEMOTHERAPY .2. 2-MONTH, DAILY ADMINISTRATION STUDY [J].