Effect of oxygen substituents on the regioselectivity of the Pd-assisted biaryl coupling reaction of benzanilides

被引：31

作者：

Harayama, T ^{[1
]}

Kawata, Y ^{[1
]}

Nagura, C ^{[1
]}

Sato, T ^{[1
]}

Miyagoe, T ^{[1
]}

Abe, H ^{[1
]}

Takeuchi, Y ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 36期

关键词：

D O I：

10.1016/j.tetlet.2005.06.167

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This study investigated the effect of oxygen substituents in the benzoyl part of N-(2-iodophenyl)benzamide on the coupling position in its Pd-assisted biaryl coupling reaction. Benzamide with methylenedioxy and acyloxy groups yielded the ortho-product formed predominantly by connection to a more hindered carbon. The mechanism is discussed from the perspectives of both steric and coordinated effects. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6091 / 6094

页数：4

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