Decomposition of bisphenol-A (BPA) by radical oxygen

A change in bisphenol-A (BPA) concentration leached from polycarbonate (PC) tube to the phosphatidyl ethanolamine (PhE)-containing water was compared to water only. Time-dependent increase in BPA concentration was observed in both samples at 37 degreesC. The leaching velocity of BPA to water was three times faster than that to PhE-containing water and BPA concentration in water reached to 55.8 ng/ml 5 weeks later. When BPA was determined immediately after BPA addition of various concentration of PhE up to 2.5mg/ml to water, the BPA recoveries were over 93%. But, when incubated at 37 degreesC for a special time, BPA concentration in PhE-containing water in glass tube decreased time-dependently. In the presence of H2O2, time and Fe-3(+) dose-dependent decrease in the BPA concentration particularly, a drastic decrease above 0.44 mM Fe-3(+) was observed. These results suggest that BPA would be decomposed by radical oxygen including lipoperoxides. An addition of serum prevented BPA decrease from radical oxygen to a great extent but could not recover the BPA decrease. Thiobarbituric acid (TBA) value, a good parameter of lipid oxidation, decreased gradually in the mixture of H2O2 and Fe-3(+) in the presence of BPA, implying an inhibition of lipid oxidation due to BPA oxidation by radical oxygen. (C) 2001 Elsevier Science Ltd. All rights reserved.