Toxoplasma gondii:: Microneme protein MIC2

被引:24
作者
Brossier, F [1 ]
Sibley, LD [1 ]
机构
[1] Washington Univ, Sch Med, Dept Microbiol, St Louis, MO 63110 USA
关键词
Toxoplasma gondii; MIC2; ICAM-1; rhomboid; aldolase;
D O I
10.1016/j.biocel.2005.06.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The phylum Apicomplexa contains parasites responsible for a variety of diseases including malaria, cryptosporidiosis, and toxoplasmosis. One of the common features of these parasites is that they contain a set of apical organelles whose sequential secretion is required for the invasion of host cells. Microneme proteins are the main adhesins involved in the attachment to the host cell surface by apicomplexans. The microneme protein MIC2, produced by Toxoplasma gondii, is conserved in apicomplexans and serves as a model to understand the first steps of invasion by the phylum. New data about the structure-function relationship of MIC2 reinforce the critical role of this protein in the successful invasion of cells by Toxoplasma and reveal potential therapeutic targets that may be used to control toxoplasmosis. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码:2266 / 2272
页数:7
相关论文
共 36 条
[1]   Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2 [J].
Barragan, A ;
Brossier, F ;
Sibley, LD .
CELLULAR MICROBIOLOGY, 2005, 7 (04) :561-568
[2]   A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma [J].
Brossier, F ;
Jewett, TJ ;
Sibley, LD ;
Urban, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (11) :4146-4151
[3]   C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells [J].
Brossier, F ;
Jewettt, TJ ;
Lovett, JL ;
Sibley, LD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) :6229-6234
[4]   Sites of interaction between aldolase and thrombospondin-related anonymous protein in Plasmodium [J].
Buscaglia, CA ;
Coppens, I ;
Hol, WGJ ;
Nussenzweig, V .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (12) :4947-4957
[5]   Secretion of micronemal proteins is associated with toxoplasma invasion of host cells [J].
Carruthers, VB ;
Giddings, OK ;
Sibley, LD .
CELLULAR MICROBIOLOGY, 1999, 1 (03) :225-235
[6]   The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases [J].
Carruthers, VB ;
Sherman, GD ;
Sibley, LD .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14346-14353
[7]  
Carruthers VB, 1997, EUR J CELL BIOL, V73, P114
[8]   Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment [J].
Carruthers, VB ;
Håkansson, S ;
Giddings, OK ;
Sibley, LD .
INFECTION AND IMMUNITY, 2000, 68 (07) :4005-4011
[9]   The cell biology of thrombospondin-1 [J].
Chen, H ;
Herndon, ME ;
Lawler, J .
MATRIX BIOLOGY, 2000, 19 (07) :597-614
[10]   Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite [J].
Dobrowolski, JM ;
Sibley, LD .
CELL, 1996, 84 (06) :933-939