Screening for early prostate cancer in Germany.: Preliminary results of a prospective multicenter trial

被引：14

作者：

Luboldt, HJ ^{[1
]}

Altwein, JE ^{[1
]}

Bichler, KH ^{[1
]}

Czaja, D ^{[1
]}

Hüsing, J ^{[1
]}

Fornara, P ^{[1
]}

Jöckel, KH ^{[1
]}

Lübben, G ^{[1
]}

Schalkhäuser, K ^{[1
]}

Weissbach, L ^{[1
]}

Wirth, M ^{[1
]}

Rübben, H ^{[1
]}

机构：

[1] Univ Essen Gesamthsch Klinikum, Urol Klin & Poliklin, D-45122 Essen, Germany

来源：

UROLOGE A | 1999年 / 38卷 / 02期

关键词：

prostate cancer; screening; PSA;

D O I：

10.1007/s001200050253

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To compare the efficacy of digital rectal examination (DRE) and serum prostate specific antigen (PSA) in early detection of prostate cancer, we initiated a prospective multicenter screening trial. In 12 542 men choosen at random with a mean age of 62 (+/- 7.5) a suspect DRE or a PSA level > 4.0 ng/ml was found in 2343 (20 %). Of the presently per formed 744 biopsies, 157 revealed diagnosis of prostate cancer. Although further biopsies as well as the follow up of the 12 542 men are still missing, combination of DRE and PSA value > 4.0 ng/ml appears to be superior to DRE alone with a positive predictive value of 50 % versus 19 % in early detection of prostate cancer.

引用

页码：114 / 123

页数：14

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