Transient impairment of the adaptive response to fasting in FXR-deficient mice

被引：73

作者：

Cariou, B

van Harmelen, K

Duran-Sandoval, D

van Dijk, T

Grefhorst, A

Bouchaert, E

Fruchart, JC

Gonzalez, FJ

Kuipers, F

Staels, B ^{[1
]}

机构：

[1] Univ Lille 2, Fac Pharm, Pasteur Inst Lille, Atherosclerosis Dept,INSERM,Res Unit 545, Lille, France

[2] Univ Groningen Hosp, Pediat Lab, Ctr Liver Digest & Metab Dis, Groningen, Netherlands

[3] NCI, Lab Metab, Div Basic Sci, NIH, Bethesda, MD 20892 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 19期

关键词：

farnesoid X receptor; fasting; PEPCK; gluconeogenesis;

D O I：

10.1016/j.febslet.2005.06.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transient lower in FXR(-/-)mice after 6 h of fasting and was decreased in FXR(-/-)hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：4076 / 4080

页数：5

共 17 条

[1] HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS - A BIOCHEMICAL AND FINE STRUCTURAL STUDY [J].