Development of Tc-99m labeled tropanes: TRODAT-1, as a dopamine transporter imaging agent

被引：40

作者：

Kung, HF ^{[1
]}

机构：

[1] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2001年 / 28卷 / 05期

关键词：

Parkinson's disease; cocaine derivatives; SPECT; PET; CNS receptors;

D O I：

10.1016/S0969-8051(01)00220-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Advances in the technetium chemistry have significantly enhanced the development of Tc-99m radiopharmaceuticals for clinical use. Efforts in designing novel Tc-99m labeled receptor or. site-specific imaging agents using [(TcO)-O-v]+3N2S2 core have produced useful imaging agents for single photo emission computed tomography (SPECT). The success in developing Tc-99m TRODAT-1 for CNS dopamine transporters (DAT) serves as the. first example of Tc-99m site-specific imaging of human brain. New innovative Tc-99m labeled site-specific agents are particularly suitable to develop simple and useful routine diagnostic procedures. (C) 2001 Elsevier Science Inc. All rights reserved.

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收藏

页码：505 / 508

页数：4

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