Pathological Gambling in Parkinson's Disease-A Review of the Literature

被引:37
作者
Djamshidian, Atbin [1 ,2 ]
Cardoso, Francisco [3 ]
Grosset, Donald [4 ]
Bowden-Jones, Henrietta [5 ,6 ]
Lees, Andrew J. [1 ,2 ]
机构
[1] Univ London, Dept Mol Neurosci, London, England
[2] Univ London, Reta Lila Weston Inst Neurol Studies, London, England
[3] Univ Fed Minas Gerais, Movement Disorders Grp, Neurol Serv, Dept Internal Med, Belo Horizonte, MG, Brazil
[4] So Gen Hosp, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland
[5] CNWL Natl Problem Gambling Clin, London, England
[6] Univ London Imperial Coll Sci Technol & Med, London, England
关键词
Parkinson's disease; pathological gambling; dopamine agonists; impulse control; adverse effects; compulsions; IMPULSE CONTROL DISORDERS; NATIONAL EPIDEMIOLOGIC SURVEY; STRIATAL DOPAMINE RELEASE; DECISION-MAKING; RISK-FACTORS; COMPULSIVE BEHAVIORS; SENSATION SEEKING; TOURETTE-SYNDROME; NOVELTY SEEKING; COCAINE;
D O I
10.1002/mds.23821
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
The prevalence of pathological gambling is 3.4% to 6% in treated Parkinson's disease, which is higher than the background population rate. In this review we discuss current evidence to indicate that dopamine agonists are much more likely to trigger this behavior than either L-dopa or selective monoamine oxidase B inhibitor monotherapy. New insights from recent behavioral and functional imaging studies and possible treatment approaches are also covered. A PubMed literature search using the terms "gambling" and "Parkin-son's disease," "impulse control disorder," "impulsive compulsive behaviour," "dopamine agonist," of individual dopamine agonists, and of ongoing drug trials, using http://www.clinicaltrials.gov, was carried out for the period up to January 2011. (C) 2011 Movement Disorder Society
引用
收藏
页码:1976 / 1984
页数:9
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