Recent advances in the IL-17 cytokine family

被引：260

作者：

Gaffen, Sarah L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Med, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CHRONIC MUCOCUTANEOUS CANDIDIASIS; ROR-GAMMA-T; TH17; CELLS; HOST-DEFENSE; TRANSCRIPTIONAL REGULATION; SIGNAL-TRANSDUCTION; T(H)17 CELLS; TGF-BETA; IN-VIVO; RECEPTOR;

D O I：

10.1016/j.coi.2011.07.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The IL-17/IL-17 receptor family is the newest and least understood of the cytokine subclasses. Composed of ligands IL-17A-IL-17F and receptors IL-17RA-IL-17RE, these cytokines have many unique structural and functional features. Since the discovery of the 'Th17' subset in 2005, particular attention has been paid to IL-17A and IL-17F and their cognate receptors. To dale, far less is known about the rest of the family. This review discusses recent advances in the field, with an emphasis on IL-17A biology.

引用

页码：613 / 619

页数：7

共 82 条

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