Seeing strangers or announcing "danger": Galectin-3 in two models of innate immunity

被引：126

作者：

Sato, S ^{[1
]}

Nieminen, J ^{[1
]}

机构：

[1] Univ Laval, Med Ctr, Ctr Hosp Univ Quebec, Res Ctr Infect Dis,Glycobiol Lab, Ste Foy, PQ, Canada

来源：

GLYCOCONJUGATE JOURNAL | 2002年 / 19卷 / 7-9期

基金：

加拿大健康研究院;

关键词：

galectin-3; innate immunity; infectious diseases; the danger model; the self-nonself model;

D O I：

10.1023/B:GLYC.0000014089.17121.cc

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent investigations on the molecular mechanisms by which our immune system recognizes infections and initiates defense against those infections have led to the proposition of two models explaining the way our innate immunity system functions; the self-nonself model and the Danger model. In this review, the roles of galectin-3 in innate immunity against infections-host-pathogen interactions-will be discussed. We will shed light on the potential contribution of a beta-galactoside binding mammalian lectin, galectin-3 as a molecule implicated in innate immunity from the angle of both the self-nonself model and the Danger model.

引用

页码：583 / 591

页数：9

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