Topographically induced direct cell mechanotransduction

被引：165

作者：

Dalby, MJ ^{[1
]}

机构：

[1] Univ Glasgow, Ctr Cell Engn, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

来源：

MEDICAL ENGINEERING & PHYSICS | 2005年 / 27卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

cytoskeleton; mechanotransduction; tensegrity; percolation; topography; nanotopography;

D O I：

10.1016/j.medengphy.2005.04.005

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This review is designed to introduce the cytoskeleton and then discuss how mechanical forces may be transduced to the cell nucleus. In addition to this, it also tries to explain current thinking as to how the nucleus turns these mechanical cues into gene changes and is especially interested in mechanotransduction arising from topographically induced morphological changes, specifically nanotopography. Thus, this review also describes cell responses to topography. (c) 2005 IPEM. Published by Elsevier Ltd. All rights reserved.

引用

页码：730 / 742

页数：13

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