The physiological significance and potential clinical applications of ghrelin

被引：25

作者：

Akamizu, Takashi ^{[1
,2
]}

Kangawa, Kenji ^{[3
]}

机构：

[1] Kyoto Univ, Sch Med, Kyoto Univ Hosp,Sakyo Ku, Dept Expt Therapeut,Translat Res Ctr,Ghrelin Res, Kyoto 6068507, Japan

[2] Wakayama Med Univ, Dept Med 1, Wakayama 6418509, Japan

[3] Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Biochem, Osaka 5658565, Japan

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2012年 / 23卷 / 03期

关键词：

Cachexia; Anorexia nervosa; GH deficiency; Clinical trial; Ghrelin; Gastrectomy; GROWTH-HORMONE SECRETAGOGUE; DES-OCTANOYL GHRELIN; BODY-WEIGHT LOSS; FOOD-INTAKE; UBIQUITIN LIGASES; ACYLATED GHRELIN; FUNCTIONAL DYSPEPSIA; ANOREXIA-NERVOSA; ELDERLY PATIENTS; NEUROPEPTIDE-Y;

D O I：

10.1016/j.ejim.2011.12.001

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Ghrelin, a natural ligand for the growth hormone (GH)-secretagogue receptor (GHS-R), is now known to play a role in a number of different physiological processes. For example, ghrelin increases GH secretion, feeding, and body weight when administered centrally or peripherally. These unique effects of ghrelin should be invaluable for the development of novel treatments and disease diagnostic techniques. Clinical trials have already been performed to assess the utility of ghrelin for the treatment of several disorders including anorexia, cachexia, and GH-related disorders. This review summarizes the recent advances in this area of research. (C) 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

引用

页码：197 / 202

页数：6

共 100 条

[1]

Effects of Ghrelin Administration After Total Gastrectomy: A Prospective, Randomized, Placebo-Controlled Phase II Study [J].

Adachi, Shinichi ;

Takiguchi, Shuji ;

Okada, Kazuyuki ;

Yamamoto, Kazuyoshi ;

Yamasaki, Makoto ;

Miyata, Hiroshi ;

Nakajima, Kiyokazu ;

Fujiwara, Yoshiyuki ;

Hosoda, Hiroshi ;

Kangawa, Kenji ;

Mori, Masaki ;

Doki, Yuichiro .

GASTROENTEROLOGY, 2010, 138 (04) :1312-1320

[2]

Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-1 levels and bowel movement frequency and negatively with systolic blood pressure [J].

Akamizu, T ;

Murayama, T ;

Teramukai, S ;

Miura, K ;

Bando, I ;

Irako, T ;

Iwakura, H ;

Ariyasu, H ;

Hosoda, H ;

Tada, H ;

Matsuyama, A ;

Kojima, S ;

Wada, T ;

Wakatsuki, Y ;

Matsubayashi, K ;

Kawakita, T ;

Shimizu, A ;

Fukushima, M ;

Yokode, M ;

Kangawa', K .

JOURNAL OF ENDOCRINOLOGY, 2006, 188 (02) :333-344

[3]

Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects [J].

Akamizu, T ;

Takaya, K ;

Irako, T ;

Hosoda, H ;

Teramukai, S ;

Matsuyama, A ;

Tada, H ;

Miura, K ;

Shimizu, A ;

Fukushima, M ;

Yokode, M ;

Tanaka, K ;

Kangawa, K .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2004, 150 (04) :447-455

[4]

Repeated administration of ghrelin to patients with functional dyspepsia: its effects on food intake and appetite [J].

Akamizu, Takashi ;

Iwakura, Hiroshi ;

Ariyasu, Hiroyuki ;

Hosoda, Hiroshi ;

Murayama, Toshinori ;

Yokode, Masayuki ;

Teramukai, Satoshi ;

Seno, Hiroshi ;

Chiba, Tsutomu ;

Noma, Shunichi ;

Nakai, Yoshikatsu ;

Fukunaga, Mikhiko ;

Nakai, Yoshihide ;

Kangawa, Kenji .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2008, 158 (04) :491-498

[5]

Translational research on the clinical applications of ghrelin [J].

Akamizu, Takashi ;

Kangawa, Kenji .

ENDOCRINE JOURNAL, 2006, 53 (05) :585-591

[6]

Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect [J].

Akamizu, Takashi ;

Kangawa, Kenji .

PEPTIDES, 2011, 32 (11) :2295-2300

[7]

EFFECTS OF GHRELIN TREATMENT ON PATIENTS UNDERGOING TOTAL HIP REPLACEMENT FOR OSTEOARTHRITIS: DIFFERENT OUTCOMES FROM STUDIES IN PATIENTS WITH CARDIAC AND PULMONARY CACHEXIA [J].

Akamizu, Takashi ;

Iwakura, Hiroshi ;

Ariyasu, Hiroyuki ;

Murayama, Toshinori ;

Sumi, Eriko ;

Teramukai, Satoshi ;

Goto, Koji ;

Ohnishi, Eijiro ;

Akiyama, Haruhiko ;

Kawanabe, Keiichi ;

Nankaku, Manabu ;

Ichihashi, Noriaki ;

Tsuboyama, Tadao ;

Tamai, Ken ;

Kataoka, Masako ;

Nakamura, Takashi ;

Kangawa, Kenji .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2008, 56 (12) :2363-2365

[8]

Cachexia in chronic heart failure: prognostic implications and novel therapeutic approaches. [J].

Akashi Y.J. ;

Springer J. ;

Anker S.D. .

Current Heart Failure Reports, 2005, 2 (4) :198-203

[9]

[Anonymous], 1992, Diagnostic and statistical manual of mental disorders, V4th

[10]

Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans [J].

Ariyasu, H ;

Takaya, K ;

Tagami, T ;

Ogawa, Y ;

Hosoda, K ;

Akamizu, T ;

Suda, M ;

Koh, T ;

Natsui, K ;

Toyooka, S ;

Shirakami, G ;

Usui, T ;

Shimatsu, A ;

Doi, K ;

Hosoda, H ;

Kojima, M ;

Kangawa, K ;

Nakao, K .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10) :4753-4758

← 1 2 3 4 5 6 7 8 9 10 →