Oestrogen receptor-α variant mRNA expression in primary human breast tumours and matched lymph node metastases

被引:4
作者
Leygue, E
Hall, RE
Dotzlaw, H
Watson, PH
Murphy, LC [1 ]
机构
[1] Univ Manitoba, Dept Biochem & Mol Biol, Winnipeg, MB R3T 2N2, Canada
[2] Flinders Univ S Australia, Dept Surg, Bedford Pk, SA 5042, Australia
[3] Univ Manitoba, Dept Pathol, Winnipeg, MB R3T 2N2, Canada
基金
英国医学研究理事会;
关键词
oestrogen receptor-alpha variants; breast cancer; metastasis;
D O I
10.1038/sj.bjc.6690156
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have shown previously that the relative expression of a truncated oestrogen receptor-alpha variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours, In this study, we have examined the relative expression of clone 4-truncated, exon 5-deleted and exon 7-deleted oestrogen receptor-alpha variant mRNAs in 15 primary breast tumour samples and in synchronous axillary lymph node metastases. Overall, there were no significant differences between the primary tumours and the matched metastases in the relative expression of these three specific variant mRNAs. Furthermore, the pattern of all deleted oestrogen receptor-alpha Variant mRNAs appeared conserved between any primary and its matched secondary tumour.
引用
收藏
页码:978 / 983
页数:6
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