CpG oligonucleotides induce the differentiation of CD4+Th17 cells by triggering plasmacytoid dendritic cells in adoptively cell transfer immunotherapy

被引：20

作者：

Xu, Lin ^{[2
]}

Wang, Chunhong ^{[3
]}

Zhou, Ya ^{[4
]}

Ren, Tao ^{[5
]}

Wen, Zhenke ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Dept Immunol, Inst Immunobiol, Shanghai 200032, Peoples R China

[2] Zunyi Med Coll, Dept Immunol, Guizhou, Peoples R China

[3] Qingdao Chest Hosp, Dept Chest Med, Shandong, Peoples R China

[4] Zunyi Med Coll, Dept Med Phys, Guizhou, Peoples R China

[5] Tongji Univ, E Hosp, Sch Med, Dept Resp Med, Shanghai, Peoples R China

来源：

IMMUNOLOGY LETTERS | 2012年 / 142卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

CpG oligonucleotide; Tumor infiltrating lymphocyte; Th17; cell; Plasmacytoid dendritic cell; TUMOR-GROWTH; LUNG-CANCER; THERAPY; TH17; RESPONSES; MELANOMA; SUBSETS;

D O I：

10.1016/j.imlet.2011.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Our previous data showed that CpG-ODNs could significantly enhance the anti-tumor efficacy of adoptively cell transfer (ACT), which was closely correlated to accumulation of Th17 cells in tumor mass. Here we further investigated that CpG-ODNs had no significant effect on the migration and proliferation capacity of Th17 cells in tumor mass. Instead, we showed that CpG-ODNs could induce the differentiation of Th17 cells via dendritic cells (DCs) in tumor infiltrating lymphocytes (TILs). Notably, we found that plasmacytoid dendritic cells (pDCs), but not myeloid dendritic cells (mDCs), were responsible for the Th17 differentiation induced by CpG-ODNs via IL-6, TGF-beta and IFN-alpha in vitro. Finally, we revealed that CpG-ODNs could stimulate pDCs to induce the differentiation of Th17 cells in vivo, which subsequently reduced the tumor size and prolonged the survival of tumor bearing nude mice. These data provided a novel insight into the mechanism of anti-tumor efficacy of CpG-ODNs based therapeutic strategy. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：55 / 63

页数：9

共 28 条

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Th17: the third member of the effector T cell trilogy [J].