The synthesis, characterization and antibacterial activity of quaternized poly(2,6-dimethyl-1,4-phenylene oxide)s modified with ammonium and phosphonium salts

被引：73

作者：

Chang, Hsin-I ^{[2
]}

Yang, Ming-Syun ^{[1
]}

Liang, Mong ^{[1
]}

机构：

[1] Natl Chiayi Univ, Dept Appl Chem, Chiayi 60004, Taiwan

[2] Natl Chiayi Univ, Dept Biochem Sci & Technol, Chiayi 60004, Taiwan

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2010年 / 70卷 / 12期

关键词：

Antimicrobial polymers; Quaternized PPO; Poly(phenylene oxide); Phosphonium salt; Ammonium salt; ANTIMICROBIAL ACTIVITY; ESCHERICHIA-COLI; BIOCIDAL POLYMERS; CATIONIC BIOCIDES; CHITOSAN; COPOLYMERS; POLYCATIONS; DERIVATIVES; METHACRYLATE; POLYSTYRENES;

D O I：

10.1016/j.reactfunctpolym.2010.09.005

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

A new class of antimicrobial polymers consisting of PPO (polyphenylene oxide) was synthesized, and the antimicrobial activities of these polymers were investigated. This was accomplished by selective alpha-bromination of PPO (BPPO) followed by quaternization reactions with various tertiary amines or phosphines. Two types of BPPO were prepared, and the antimicrobial activities of the quaternized polymers were tested against Gram-positive bacteria (S. Epidermidis) and Gram-negative bacteria (Escherichia. coli). The triphenylphosphonium-modified polymer showed excellent antibacterial activity against both types of bacteria. Generally, the thermal stability of phosphonium-modified BPPO was superior to that of the ammonium analog, and the increase in the functionalization of the polymer backbone resulted in improved antimicrobial activity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：944 / 950

页数：7

共 49 条

[1]

Diethylmethyl chitosan as an antimicrobial agent: Synthesis, characterization and antibacterial effects [J].