Selective detection of dopamine in the presence of ascorbic acid and uric acid by a carbon nanotubes-ionic liquid gel modified electrode

被引:408
作者
Zhao, YF [1 ]
Gao, YQ [1 ]
Zhan, DP [1 ]
Liu, H [1 ]
Zhao, Q [1 ]
Kou, Y [1 ]
Shao, YH [1 ]
Li, MX [1 ]
Zhuang, QK [1 ]
Zhu, ZW [1 ]
机构
[1] Peking Univ, Coll Chem & Mol Engn, Inst Analyt Chem, Beijing 100871, Peoples R China
基金
中国国家自然科学基金;
关键词
carbon nanotubes; ionic liquid; dopamine; ascorbic acid; modified electrode;
D O I
10.1016/j.talanta.2004.09.019
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The electrochemistry of dopamine (DA) was studied by cyclic voltammetry at a glassy carbon electrode modified by a gel containing multiwalled carbon nanotubes (MWNTs) and room-temperature ionic liquid of 1-octyl-3-methylimidazolium hexafluorophosphate (OMIMPF6). The thickness of gel on the surface of the electrode has to be controlled carefully because the charging currents increase with the modified layer being thicker. The anodic peaks of DA, ascorbic acid (AA) and uric acid (UA) in their mixture can be well separated since the peak potential of AA is shifted to more negative values, while that of UA is shifted to more positive values due to the modified electrode. At pH 7.08 the three peaks are separated ca. 0.20 and 0.15 V, respectively; hence DA can be determined in the presence of UA and more than 100 times excess of AA. Under optimum conditions linear calibration graphs were obtained over the DA concentration range 1.0 x 10(-6) to 1.0 x 10(-4) M. The detection limit of the current technique was found to be 1.0 x 10(-7) M based on the signal-to-noise ratio of 3. The modified electrode has been successfully applied for the assay of DA in human blood serum. This work provides a simple and easy approach to selectively detect dopamine in the presence of ascorbic acid and uric acid. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:51 / 57
页数:7
相关论文
共 38 条
[1]   Investigation of modified basal plane pyrolytic graphite electrodes: definitive evidence for the electrocatalytic properties of the ends of carbon nanotubes [J].
Banks, CE ;
Moore, RR ;
Davies, TJ ;
Compton, RG .
CHEMICAL COMMUNICATIONS, 2004, (16) :1804-1805
[2]   Detection of dopamine in the presence of a large excess of ascorbic acid by using the powder microelectrode technique [J].
Chen, J ;
Cha, CS .
JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1999, 463 (01) :93-99
[3]  
CHEN M, 2003, ELECTROANAL, V7, P477
[4]   Polyeugenol-modified platinum electrode for selective detection of dopamine in the presence of ascorbic acid [J].
Ciszewski, A ;
Milczarek, G .
ANALYTICAL CHEMISTRY, 1999, 71 (05) :1055-1061
[5]   Covalent modification of carbon electrodes for voltammetric differentiation of dopamine and ascorbic acid [J].
Downard, AJ ;
Roddick, AD ;
Bond, AM .
ANALYTICA CHIMICA ACTA, 1995, 317 (1-3) :303-310
[6]   Molecular ordering of organic molten salts triggered by single-walled carbon nanotubes [J].
Fukushima, T ;
Kosaka, A ;
Ishimura, Y ;
Yamamoto, T ;
Takigawa, T ;
Ishii, N ;
Aida, T .
SCIENCE, 2003, 300 (5628) :2072-2074
[7]   99.9% purity multi-walled carbon nanotubes by vacuum high-temperature annealing [J].
Huang, W ;
Wang, Y ;
Luo, GH ;
Wei, F .
CARBON, 2003, 41 (13) :2585-2590
[8]   Room temperature ionic liquids as novel media for 'clean' liquid-liquid extraction [J].
Huddleston, JG ;
Willauer, HD ;
Swatloski, RP ;
Visser, AE ;
Rogers, RD .
CHEMICAL COMMUNICATIONS, 1998, (16) :1765-1766
[9]   HELICAL MICROTUBULES OF GRAPHITIC CARBON [J].
IIJIMA, S .
NATURE, 1991, 354 (6348) :56-58
[10]   Novel three-dimensional electrodes: Electrochemical properties of carbon nanotube ensembles [J].
Li, J ;
Cassell, A ;
Delzeit, L ;
Han, J ;
Meyyappan, M .
JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (36) :9299-9305