Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity

被引：360

作者：

Ohno, S ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Mol Biol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(00)00264-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Two PDZ-domain-containing adapter-like proteins, PAR-3 and PAR-6, and a protein kinase, atypical protein kinase C (PKC), cooperate together to establish cell polarity in a variety of biological contexts. These include asymmetric cell division in early Caenorhabditis elegans embryo and Drosophila neuroblasts, as well as the establishment and maintenance of apical-basal polarity in Drosophila and mammalian epithelial cells. Recent studies on the role of this PAR-aPKC complex in epithelia[ cell polarization provide new insights into the molecular basis of epithelial junctional formation and cell polarity.

引用

页码：641 / 648

页数：8

共 67 条

[61] Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process [J].

Wallenfang, MR ;

Seydoux, G .

NATURE, 2000, 408 (6808) :89-92

[62] Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts [J].

Wodarz, A ;

Ramrath, A ;

Grimm, A ;

Knust, E .

JOURNAL OF CELL BIOLOGY, 2000, 150 (06) :1361-1374

[63] Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts [J].

Wodarz, A ;

Ramrath, A ;

Kuchinke, U ;

Knust, E .

NATURE, 1999, 402 (6761) :544-547

[64]

YAMANAKA T, 2001, IN PRESS GENES CELL

[65] Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization [J].

Yu, FW ;

Morin, X ;

Cai, Y ;

Yang, XH ;

Chia, W .

CELL, 2000, 100 (04) :399-409

[66] Tight junction, a platform for trafficking and signaling protein complexes [J].

Zahraoui, A ;

Louvard, D ;

Galli, T .

JOURNAL OF CELL BIOLOGY, 2000, 151 (05) :F31-F36

[67] G proteins are required for spatial orientation of early cell cleavages in C. elegans embryos [J].

Zwaal, RR ;

Ahringer, J ;

vanLuenen, HGAM ;

Rushforth, A ;

Anderson, P ;

Plasterk, RHA .

CELL, 1996, 86 (04) :619-629

← 1 2 3 4 5 6 7 →