Human dendritic cell deficiency: the missing ID?

被引：86

作者：

Collin, Matthew ^{[1
]}

Bigley, Venetia ^{[1
]}

Haniffa, Muzlifah ^{[1
]}

Hambleton, Sophie ^{[1
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

LEUKEMIA-LIKE SYNDROME; IN-VIVO; T-CELLS; DISTINCT POPULATIONS; TRANSCRIPTION FACTOR; SUBSET DEVELOPMENT; IMMUNE-RESPONSES; LANGERHANS CELLS; INFLUENZA-VIRUS; 6-SULFO LACNAC;

D O I：

10.1038/nri3046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Animal models and human in vitro systems indicate that dendritic cells (DCs) have a crucial role in priming naive T cells, but just how important are they in the intact human? Recent descriptions of human DC deficiency have begun to shed light on this question and to illuminate other puzzles of human DC biology, including their haematopoietic origin, developmental regulation and homeostatic equilibrium with other leukocytes. In this Review, we explore the recently described DC deficiency syndromes, discussing what these have taught us with regard to DC function in humans and the important issues that remain unsolved.

引用

页码：575 / 583

页数：9

共 89 条

[1]

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential:: A revised road map for adult blood lineage commitment [J].

Adolfsson, J ;

Månsson, R ;

Buza-Vidas, N ;

Hultquist, A ;

Liuba, K ;

Jensen, CT ;

Bryder, D ;

Yang, LP ;

Borge, OJ ;

Thoren, LAM ;

Anderson, K ;

Sitnicka, E ;

Sasaki, Y ;

Sigvardsson, M ;

Jacobsen, SEW .

CELL, 2005, 121 (02) :295-306

[2]

Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells [J].

Aliberti, J ;

Schulz, O ;

Pennington, DJ ;

Tsujimura, H ;

Sousa, CRE ;

Ozato, K ;

Sher, A .

BLOOD, 2003, 101 (01) :305-310

[3]

CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts [J].

Angel, Catherine E. ;

Lala, Aisha ;

Chen, Chun-Jen J. ;

Edgar, Stephen G. ;

Ostrovsky, Lena L. ;

Dunbar, P. Rod .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (11) :1271-1279

[4]

Distinctive localization of antigen-presenting cells in human lymph nodes [J].

Angel, Catherine E. ;

Chen, Chun-Jen J. ;

Horlacher, Oliver C. ;

Winkler, Sintia ;

John, Thomas ;

Browning, Judy ;

MacGregor, Duncan ;

Cebon, Jonathan ;

Dunbar, P. Rod .

BLOOD, 2009, 113 (06) :1257-1267

[5]

Evaluation of a 12-Color Flow Cytometry Panel to Study Lymphocyte, Monocyte, and Dendritic Cell Subsets in Humans [J].

Autissier, Patrick ;

Soulas, Caroline ;

Burdo, Tricia H. ;

Williams, Kenneth C. .

CYTOMETRY PART A, 2010, 77A (05) :410-419

[6]

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells [J].

Bachem, Annabell ;

Guettler, Steffen ;

Hartung, Evelyn ;

Ebstein, Frederic ;

Schaefer, Michael ;

Tannert, Astrid ;

Salama, Abdulgabar ;

Movassaghi, Kamran ;

Opitz, Corinna ;

Mages, Hans W. ;

Henn, Volker ;

Kloetzel, Peter-Michael ;

Gurka, Stephanie ;

Kroczek, Richard A. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (06) :1273-1281

[7]

Defining dendritic cells by conditional and constitutive cell ablation [J].

Bar-On, Liat ;

Jung, Steffen .

IMMUNOLOGICAL REVIEWS, 2010, 234 :76-89

[8]

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency [J].

Bigley, Venetia ;

Haniffa, Muzlifah ;

Doulatov, Sergei ;

Wang, Xiao-Nong ;

Dickinson, Rachel ;

McGovern, Naomi ;

Jardine, Laura ;

Pagan, Sarah ;

Dimmick, Ian ;

Chua, Ignatius ;

Wallis, Jonathan ;

Lordan, Jim ;

Morgan, Cliff ;

Kumararatne, Dinakantha S. ;

Doffinger, Rainer ;

van der Burg, Mirjam ;

van Dongen, Jacques ;

Cant, Andrew ;

Dick, John E. ;

Hambleton, Sophie ;

Collin, Matthew .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (02) :227-234

[9]

Lack of Conventional Dendritic Cells Is Compatible with Normal Development and T Cell Homeostasis, but Causes Myeloid Proliferative Syndrome [J].

Birnberg, Tal ;

Bar-On, Liat ;

Sapoznikov, Anita ;

Caton, Michele L. ;

Cervantes-Barragan, Luisa ;

Makia, Divine ;

Krauthgamer, Rita ;

Brenner, Ori ;

Ludewig, Burkhard ;

Brockschnieder, Damian ;

Riethmacher, Dieter ;

Reizis, Boris ;

Jung, Steffen .

IMMUNITY, 2008, 29 (06) :986-997

[10]

Origin of the Lamina Propria Dendritic Cell Network [J].

Bogunovic, Milena ;

Ginhoux, Florent ;

Helft, Julie ;

Shang, Limin ;

Hashimoto, Daigo ;

Greter, Melanie ;

Liu, Kang ;

Jakubzick, Claudia ;

Ingersoll, Molly A. ;

Leboeuf, Marylene ;

Stanley, E. Richard ;

Nussenzweig, Michel ;

Lira, Sergio A. ;

Randolph, Gwendalyn J. ;

Merad, Miriam .

IMMUNITY, 2009, 31 (03) :513-525

← 1 2 3 4 5 6 7 8 9 →