Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle

被引:57
作者
Kubo, Satoko [1 ]
Doe, Ichiko [1 ]
Kurokawa, Yuko [1 ]
Kawabata, Atsufumi [1 ]
机构
[1] Kinki Univ, Sch Pharm, Div Pharmacol & Pathophysiol, Higashiosaka, Osaka 5778502, Japan
关键词
hydrogen sulfide (H2S); smooth muscle; bronchodilation;
D O I
10.1254/jphs.SC0070199
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01-10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1-3 mM strongly relaxed the mouse rings, but produced only slight relaxation in the guinea-pig rings. The NaHS-induced relaxation in the mouse bronchus was resistant to inhibitors of ATP-sensitive K+ channels, soluble guanylyl cyclase, cyclooxygenase (COX)-1 or COX-2, and antagonists of tachykinin receptors. Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H2S in the respiratory system.
引用
收藏
页码:392 / 396
页数:5
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