Hydrogen sulfide causes relaxation in mouse bronchial smooth muscle

被引：57

作者：

Kubo, Satoko ^{[1
]}

Doe, Ichiko ^{[1
]}

Kurokawa, Yuko ^{[1
]}

Kawabata, Atsufumi ^{[1
]}

机构：

[1] Kinki Univ, Sch Pharm, Div Pharmacol & Pathophysiol, Higashiosaka, Osaka 5778502, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2007年 / 104卷 / 04期

关键词：

hydrogen sulfide (H2S); smooth muscle; bronchodilation;

D O I：

10.1254/jphs.SC0070199

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01-10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1-3 mM strongly relaxed the mouse rings, but produced only slight relaxation in the guinea-pig rings. The NaHS-induced relaxation in the mouse bronchus was resistant to inhibitors of ATP-sensitive K+ channels, soluble guanylyl cyclase, cyclooxygenase (COX)-1 or COX-2, and antagonists of tachykinin receptors. Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H2S in the respiratory system.

引用

页码：392 / 396

页数：5

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