Clinical review 124 - Diabetic dyslipidemia: Causes and consequences

被引:373
作者
Goldberg, IJ [1 ]
机构
[1] Columbia Univ Coll Phys & Surg, Div Prevent Med & Nutr, New York, NY 10032 USA
关键词
D O I
10.1210/jc.86.3.965
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Much of the pathophysiology linking diabetes and dyslipidemia has been elucidated. Although undoubtedly of importance, diabetic dyslipidemia is likely to be but one of many reasons for the accelerated macrovascular disease in diabetic patients. Nonetheless, treatment of lipid abnormalities has the potential to reduce cardiovascular events more than 50%, to rates that are seen in countries with lower cholesterol and less atherosclerotic burden. This leads to the expectation that treatment of elevated lipid levels will allow patients with diabetes to lead longer healthier lives.
引用
收藏
页码:965 / 971
页数:7
相关论文
共 67 条
[21]   CARDIOVASCULAR RISK-FACTORS IN CONFIRMED PREDIABETIC INDIVIDUALS - DOES THE CLOCK FOR CORONARY HEART-DISEASE START TICKING BEFORE THE ONSET OF CLINICAL DIABETES [J].
HAFFNER, SM ;
STERN, MP ;
HAZUDA, HP ;
MITCHELL, BD ;
PATTERSON, JK .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (21) :2893-2898
[22]   Management of dyslipidemia in adults with diabetes [J].
Haffner, SM .
DIABETES CARE, 1998, 21 (01) :160-178
[23]   Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction [J].
Haffner, SM ;
Lehto, S ;
Rönnemaa, T ;
Pyörälä, K ;
Laakso, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (04) :229-234
[24]   Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension:: principal results of the hypertension optimal treatment (HOT) randomised trial [J].
Hansson, L ;
Zanchetti, A ;
Carruthers, SG ;
Dahlöf, B ;
Elmfeldt, D ;
Julius, S ;
Ménard, J ;
Rahn, KH ;
Wedel, H ;
Westerling, S .
LANCET, 1998, 351 (9118) :1755-1762
[25]   HYPERTRIGLYCERIDEMIA AND CHOLESTERYL ESTER TRANSFER PROTEIN INTERACT TO DRAMATICALLY ALTER HIGH-DENSITY-LIPOPROTEIN LEVELS, PARTICLE SIZES, AND METABOLISM - STUDIES IN TRANSGENIC MICE [J].
HAYEK, T ;
AZROLAN, N ;
VERDERY, RB ;
WALSH, A ;
CHAJEKSHAUL, T ;
AGELLON, LB ;
TALL, AR ;
BRESLOW, JL .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (03) :1143-1152
[26]   INCREASED PLASMA AND RENAL CLEARANCE OF AN EXCHANGEABLE POOL OF APOLIPOPROTEIN A-I IN SUBJECTS WITH LOW-LEVELS OF HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL [J].
HOROWITZ, BS ;
GOLDBERG, IJ ;
MERAB, J ;
VANNI, TM ;
RAMAKRISHNAN, R ;
GINSBERG, HN .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1743-1752
[27]  
Howard BV, 1999, AM J CARDIOL, V84, p28J
[28]  
ISHIDA BY, 1991, J LIPID RES, V32, P559
[29]   Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels [J].
Jiang, XC ;
Bruce, C ;
Mar, J ;
Lin, M ;
Ji, Y ;
Francone, OL ;
Tall, AR .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) :907-914
[30]   Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency [J].
Julien, P ;
Vohl, MC ;
Gaudet, D ;
Gagne, C ;
Levesque, G ;
Despres, JP ;
Cadelis, F ;
Brun, LD ;
Nadeau, A ;
Murthy, MRV .
DIABETES, 1997, 46 (12) :2063-2068