Palladium-catalyzed glycosylation reaction:: De-novo synthesis of trehalose analogues

被引：45

作者：

Babu, RS ^{[1
]}

O'Doherty, GA ^{[1
]}

机构：

[1] W Virginia Univ, Dept Chem, Morgantown, WV 26506 USA

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2005年 / 24卷 / 02期

关键词：

trehalose; manno-trehalose; palladium; glycosylation; alpha-1,1-disaccharides;

D O I：

10.1081/CAR-200059959

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unnatural L-1,1-alpha-disaccharides were synthesized from acylfurans using a palladium-catalyzed glycosylation reaction. The 1,1,1-alpha-manno-disaccharides were achieved in six total steps starting from an acylfuran. The overall efficiency of this protocol was the use of highly diastereoselective palladium-catalyzed glycosylation, reduction, and dihydroxylation.

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页码：169 / 177

页数：9

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