CpG oligodeoxynucleotides increase the susceptibility of normal mice to infection by Candida albicans

被引：15

作者：

Ito, S

Pedras-Vasconcelos, J

Klinman, DM

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Sect Retroviral Immunol, Bethesda, MD 20892 USA

[2] US FDA, Ctr Biol Evaluat & Res, Div Therapeut Prot, Bethesda, MD 20892 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 09期

关键词：

D O I：

10.1128/IAI.73.9.6154-6156.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.

引用

收藏

页码：6154 / 6156

页数：3

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