Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation

Rat cisternal (CSF) hypocretin-1 in cerebrospinal fluid was measured after 6 or 96 It of REM sleep deprivation and following 24 It of REM sleep rebound. REM deprivation was found to increase CSF hypocretin-1 collected at zeitgeber time (ZT) 8 but not ZT0. Decreased CSF hypocretin levels were also observed at ZT8 after 24 It of REM sleep rebound. These results suggest that REM sleep deprivation activates and REM sleep rebound inhibits the hypocretin system. Increased hypocretin tone during REM deprivation may be important in mediating some of the effects of REM sleep deprivation such as antidepressant effects, hyperphagia and increased sympathetic activity. (C) 2003 Elsevier B.V All rights reserved.