Comparative toxicology of borates

被引:56
作者
Hubbard, SA [1 ]
机构
[1] Borax Europe Ltd, Guildford GU2 5RQ, Surrey, England
关键词
borates; boric acid; borax; reproductive toxicity; developmental toxicity;
D O I
10.1007/BF02783147
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inorganic berates, including boric acid, Na, ammonium, K, and Zn berates generally display low acute toxicity orally, dermally, and by inhalation. They are either not irritant or mild skin and eye irritants. Exceptions owing to physiochemical properties do occur. Longer-term toxicological studies have been reported mainly on boric acid or borax where the properties are generally similar on an equivalent boron (B) basis. The critical effects in several species are male reproductive toxicity and developmental toxicity. The doses that cause these effects are far higher than any levels to which the human population could be exposed. Humans would need to consume daily some 3.3 g of boric acid (or 5.0 g borax) to ingest the same dose level as the lowest animal NOAEL. No effects on fertility were seen in a population of workers exposed to berates or to a population exposed to high environmental berate levels. There is remarkable similarity in the toxicological effects of boric acid and borax across different species. Other inorganic berates that simply dissociate to boric acid are expected to display similar toxicity, whereas those that do not dissociate simply to boric acid may display a different toxicological profile.
引用
收藏
页码:343 / 357
页数:15
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