1,3-Dipolar cycloadditions to unsymmetrical ketone-derived chiral stabilized azomethine ylides: Strategies for the synthesis of highly substituted amino acids

被引：19

作者：

Aldous, DJ

Drew, MGB

Draffin, WN

Hamelin, EMN

Harwood, LM

Thurairatnam, S

机构：

[1] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England

[2] Rhone Poulenc Rorer Ltd, Dagenham RM10 7XS, Essex, England

来源：

SYNTHESIS-STUTTGART | 2005年 / 19期

关键词：

azomethine ylide; beta-hydroxy-alpha-amino acid; proline; intramolecular; cycloaddition;

D O I：

10.1055/s-2005-918487

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report herein, the first generation of unsymmetrical ketone-derived chiral stabilized azomethine ylides. Intrairiolecular and intermolecular cycloaddition strategies have been utilized to synthesize both an enantiornerically pure bicyclic proline derivative and an enantionierically pure beta-hydroxy-alpha-amino acid.

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收藏

页码：3271 / 3278

页数：8

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