Inhibitory effect of Pleurotus eryngii extracts on the activities of allergic mediators in antigen-stimulated mast cells

被引：37

作者：

Han, Eun Hee ^{[1
]}

Hwang, Yong Pil ^{[1
]}

Kim, Hyung Gyun ^{[1
]}

Choi, Jae Ho ^{[1
]}

Im, Ji Hye ^{[1
]}

Yang, Ji Hye ^{[1
]}

Lee, Hyun-Uk ^{[2
]}

Chun, Sung-Sik ^{[3
]}

Chung, Young Chu ^{[3
]}

Jeong, Hye Gwang ^{[1
]}

机构：

[1] Chungnam Natl Univ, Dept Toxicol, Coll Pharm, Taejon 305764, South Korea

[2] Mushtopia Co Ltd, Mushroom Sci Res Inst, Jinju, South Korea

[3] Korea Int Univ, Div Food Sci, Jinju, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2011年 / 49卷 / 06期

关键词：

Pleurotus eryngii; Anti-allergic activity; Mast cells; IL-4; NF-kappa B; COX-2; NF-KAPPA-B; PROTEIN-TYROSINE KINASE; MUSHROOM HYPSIZIGUS-MARMOREUS; AFFINITY IGE RECEPTOR; INDICA VAR. SABOTEN; PHOSPHOINOSITIDE; 3-KINASE; ERGOSTEROL PEROXIDE; CYTOKINE PRODUCTION; SIGNALING PATHWAYS; HISTAMINE-RELEASE;

D O I：

10.1016/j.fct.2011.03.034

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Pleurotus eryngii is an edible mushroom native to Europe, the Middle East, and North Africa, and is also grown in parts of Asia. The present study investigated the anti-allergy potential of P. eryngii extract (PEE) in antigen-stimulated RBL-2H3 mast cells. PEE inhibited allergy markers, including release of hexosaminidase and histamine, in antigen-sensitized RBL-2H3 cells. PEE also suppressed the expression and production of interleukin-4 and reduced antigen-induced NFAT and NF-kappa B transcriptional activity in antigen-sensitized mast cells. Moreover, PEE decreased the levels of proinflammatory cytokines and COX-2 and iNOS expression in antigen-sensitized mast cells. Finally. PEE suppressed antigen-induced signal protein phosphorylation of Lyn, PLC gamma 2, PKC, Akt, and MAP kinases. Taken together, these results suggest that P. eryngii extract may provide insight into the prevention and treatment of allergic and inflammatory diseases. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1416 / 1425

页数：10

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