Surface gradient of functional heparin

被引：59

作者：

Robinson, David E. ^{[3
]}

Marson, Andrew ^{[2
]}

Short, Robert D. ^{[1
]}

Buttle, David J. ^{[4
]}

Day, Anthony J. ^{[2
]}

Parry, Kristina L. ^{[5
]}

Wiles, Michelle ^{[5
]}

Highfield, Peter ^{[5
]}

Mistry, Anita ^{[3
]}

Whittle, Jason D. ^{[5
]}

机构：

[1] Univ S Australia, Mawson Inst, Adelaide, SA 5001, Australia

[2] Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester M13 9PT, Lancs, England

[3] Univ Sheffield, Dept Mat Engn, Sheffield S1 3JD, S Yorkshire, England

[4] Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Med & Rheumatol, Sheffield S10 2RX, S Yorkshire, England

[5] Plaso Technol Ltd, Innovat Ctr, Sheffield S1 4DP, S Yorkshire, England

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 06期

关键词：

D O I：

10.1002/adma.200702586

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A gradient of functional heparin is fabricated onto a surface chemical gradient of plasma-polymerized allyl amine (see figure). While heparin functionality changes across the gradient, increased adsorption of heparin onto the surface is not accompanied with a continued, corresponding rise in heparin function.

引用

页码：1166 / +

页数：5

共 29 条

[1] Control of crystal nucleation by patterned self-assembled monolayers [J].

Aizenberg, J ;

Black, AJ ;

Whitesides, GM .

NATURE, 1999, 398 (6727) :495-498

[2] Using a core-sheath distribution of surface chemistry through 3D tissue engineering scaffolds to control cell ingress [J].

Barry, John J. A. ;

Howard, Daniel ;

Shakesheff, Kevin M. ;

Howdle, Steve M. ;

Alexander, Morgan R. .

ADVANCED MATERIALS, 2006, 18 (11) :1406-+

[3] Investigating radio frequency plasmas used for the modification of polymer surfaces [J].

Barton, D ;

Bradley, JW ;

Steele, DA ;

Short, RD .

JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (21) :4423-4430

[4] Adsorption of immunoglobulin G to plasma-co-polymer surfaces of acrylic acid and 1,7-octadiene [J].

Bullett, NA ;

Whittle, JD ;

Short, RD ;

Douglas, CWI .

JOURNAL OF MATERIALS CHEMISTRY, 2003, 13 (07) :1546-1553

[5] HOW TO MAKE WATER RUN UPHILL [J].

CHAUDHURY, MK ;

WHITESIDES, GM .

SCIENCE, 1992, 256 (5063) :1539-1541

[6] Micrometer-scaled gradient surfaces generated using contact printing of octadecyltrichlorosilane [J].

Choi, SH ;

Newby, BMZ .

LANGMUIR, 2003, 19 (18) :7427-7435

[7] His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form. [J].

Clark, Simon J. ;

Higman, Victoria A. ;

Mulloy, Barbara ;

Perkins, Stephen J. ;

Lea, Susan M. ;

Sim, Robert B. ;

Day, Anthony J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (34) :24713-24720

[8] Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates [J].

Herbert, CB ;

McLernon, TL ;

Hypolite, CL ;

Adams, DN ;

Pikus, L ;

Huang, CC ;

Fields, GB ;

Letourneau, PC ;

Distefano, MD ;

Hu, WS .

CHEMISTRY & BIOLOGY, 1997, 4 (10) :731-737

[9] SYNTHESIS OF REVERSE-OSMOSIS MEMBRANES BY PLASMA POLYMERIZATION OF ALLYLAMINE [J].

HOLLAHAN, JR ;

WYDEVEN, T .

SCIENCE, 1973, 179 (4072) :500-501

[10] Effects of shear stress on endothelial cell haptotaxis on micropatterned surfaces [J].

Hsu, S ;

Thakar, R ;

Liepmann, D ;

Li, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 337 (01) :401-409

← 1 2 3 →