Botulinum toxin injections do not improve freezing of gait in Parkinson disease

被引：34

作者：

Wieler, M

Camicioli, R

Jones, A

Martin, WRW

机构：

[1] Univ Alberta, Dept Med Neurol, Edmonton, AB, Canada

[2] Univ Alberta, Dept Phys Therapy & Publ Hlth Sci, Edmonton, AB, Canada

来源：

NEUROLOGY | 2005年 / 65卷 / 04期

关键词：

D O I：

10.1212/01.wnl.0000172930.63669.c8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Freezing of gait ( FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.

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页码：626 / 628

页数：3

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