Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: Case study

被引：45

作者：

Allen, JC

Judkins, AR

Rosenblum, MK

Biegel, JA

机构：

[1] Childrens Hosp Philadelphia, Abramson Res Ctr, Dept Pathol, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Abramson Res Ctr, Dept Pediat, Philadelphia, PA 19104 USA

[3] NYU, Sch Med, Dept Neurol, New York, NY 10016 USA

[4] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

来源：

NEURO-ONCOLOGY | 2006年 / 8卷 / 01期

关键词：

atypical teratoid tumor; ganglioglioma; hSNF5/INI1; rhabdoid tumor;

D O I：

10.1215/S1522851705000347

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report an atypical teratoid/rhabdoid tumor arising in a ganglioglioma from an 11-year-old male who had been treated over a nine-year period. A combined histologic, immunohistochemical, and molecular genetic analysis confirmed this diagnosis. Molecular genetic studies demonstrated a mutation in exon 9 of the INI1 gene in the tumor, which was not present in the patient's blood. This report is the first to describe progression of a ganglioglioma to atypical teratoid/rhabdoid tumor.

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页码：79 / 82

页数：4

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