Synthesis of monodisperse biodegradable microgels in microfluidic devices

被引：138

作者：

De Geest, BG

Urbanski, JP

Thorsen, T

Demeester, J

De Smedt, SC

机构：

[1] State Univ Ghent, Lab Gen Biochem & Phys Pharm, Dept Pharmaceut, B-9000 Ghent, Belgium

[2] MIT, Dept Mech Engn, Hatsopoulos Microfluids Lab, Cambridge, MA 02139 USA

来源：

LANGMUIR | 2005年 / 21卷 / 23期

关键词：

D O I：

10.1021/la051527y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microgels are promising materials in drug delivery and biomedicine. Although monodisperse microgels would offer considerable advantages, most microgels investigated and used today are polydisperse in size. We report on the fabrication of 10 mu m sized monodisperse microgels by emulsifying an aqueous dextran-hydroxyethyl methacrylate (dex-HEMA) phase within an oil phase at the junction of microfluidic channels. Dex-HEMA microgels are biodegradable and are ideally suited for the controlled delivery of proteins.

引用

页码：10275 / 10279

页数：5

共 27 条

[1]

Albertsson P.A., 1986, PARTITION CELL PARTI

[2]

Cadée JA, 2000, J BIOMED MATER RES, V50, P397

[3]

Charcosset C, 2005, REV CHEM ENG, V21, P1

[4] GRAFT-COPOLYMERS THAT EXHIBIT TEMPERATURE-INDUCED PHASE-TRANSITIONS OVER A WIDE-RANGE OF PH [J].