The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with α-tocopherol in rat kidneys

被引：114

作者：

Irmak, MK

Koltuksuz, U ^{[1
]}

Kutlu, NO

Yagmurca, M

Özyurt, H

Karaman, A

Akyol, Ö

机构：

[1] Inonu Univ, Fac Med, Dept Pediat Surg, Malatya, Turkey

[2] Inonu Univ, Fac Med, Dept Biochem, Malatya, Turkey

[3] Inonu Univ, Fac Med, Dept Pediat, Malatya, Turkey

[4] Inonu Univ, Fac Med, Dept Histol & Embryol, Malatya, Turkey

来源：

UROLOGICAL RESEARCH | 2001年 / 29卷 / 03期

关键词：

reperfusion injury; kidney; caffeic acid phenethyl ester; alpha-tocopherol;

D O I：

10.1007/s002400100185

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant and anti-inflammatory properties. To determine whether CAPE offers any advantage over alpha -tocopherol, we compared their effects on an in vivo model of renal ischemia-reperfusion injury in rats. CAFE at 10 mu mol/kg or alpha -tocopherol at 10 mg/kg was administered intraperitoneally before reperfusion. Acute administration of CAFE suppressed ischemia-reperfusion induced renal lipid peroxidation and tissue injury more than alpha -tocopherol. CAFE may therefore offer a therapeutic advantage in acute injury settings.

引用

页码：190 / 193

页数：4

共 19 条

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