The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system

被引：562

作者：

Funes, S ^{[1
]}

Hedrick, JA ^{[1
]}

Vassileva, G ^{[1
]}

Markowitz, L ^{[1
]}

Abbondanzo, S ^{[1
]}

Golovko, A ^{[1
]}

Yang, SJ ^{[1
]}

Monsma, FJ ^{[1
]}

Gustafson, EL ^{[1
]}

机构：

[1] Schering Plough Corp, Res Inst, Discovery Technol Dept, Func Genomics Res, Kenilworth, NJ 07033 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 312卷 / 04期

关键词：

GPR54; reproductive function; metastin; KiSS-1; knockout mouse;

D O I：

10.1016/j.bbrc.2003.11.066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GPR54 is a G-protein-coupled receptor that displays a high percentage of identity in the transmembrane domains with the galanin receptors. The ligand for GPR54 has been identified as a peptide derived from the KiSS-1 gene. KiSS-1 has been shown to have anti-metastatic effects, suggesting that KiSS-1 or its receptor represents a potential therapeutic target. To further our understanding of the physiological function of this receptor, we have generated a mutant mouse line with a targeted disruption of the GPR54 receptor (GPR54 -/-). The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features. These data suggest a role for GPR54/KiSS-1 in normal sexual development, and indicate that study of the GPR54 mutant mice may provide valuable insights into human reproductive syndromes. (C) 2003 Elsevier Inc. All rights reserved.

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收藏

页码：1357 / 1363

页数：7

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