Relationship of adiponectin to serum paraoxonase 1

被引:29
作者
Bajnok, Laszlo [1 ,4 ]
Csongradi, Eva [4 ]
Seres, Ildiko [4 ]
Varga, Zsuzsa [4 ]
Jeges, Sara [2 ]
Peti, Attila [3 ]
Karanyi, Zsolt [4 ]
Juhasz, Attila [4 ]
Mezosi, Emese [1 ,4 ]
Nagy, Endre V. [4 ]
Paragh, Gyorgy [4 ]
机构
[1] Univ Pecs, Dept Med 1, Sch Med, H-7624 Pecs, Hungary
[2] Univ Pecs, Inst Bioanal, Sch Med & Appl Hlth Sci, Fac Hlth Sci, H-7624 Pecs, Hungary
[3] Univ Pecs, Fac Med, Inst Lab Med, H-7624 Pecs, Hungary
[4] Univ Debrecen, Dept Med 1, Med & Hlth Sci Ctr, H-4012 Debrecen, Hungary
关键词
obesity; adiponectin; serum paraoxonase 1; lipid peroxidation;
D O I
10.1016/j.atherosclerosis.2007.06.001
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Correlation of the plasma levels of insulin-sensitizing, anti-inflammatory and anti-atherosclerotic adiponectin with HDL has been demonstrated. However, its relation to HDL-bound paraoxonase 1 (PON1) has not been clarified. The association of serum PON1 activity with findings of metabolic syndrome was investigated in three age and sex-matched groups: (1) non-diabetic overweight subjects with BMT 28-39.9 kg/m(2) (n = 25); (2) non-diabetic obese subjects with BMI >= 40 kg/m(2) (n = 25); and (3) healthy, normal-weight controls (n = 24). Of the parameters investigated, PON1 activity correlated positively with concentrations of HDL-C and adiponectin, and correlated negatively with BMI, waist circumference, systolic BP, levels of HbA(1C), and insulin, HOMA-IR, and TBARS. The positive correlation between adiponectin and PON1 remained significant even after adjustments for age, gender, BMI, blood pressure, HOMA-IR, HDL-C, LDL-C, and lipid peroxidation. Conclusions: PON1 activity shows negative association with markers of metabolic syndrome. We demonstrate that adiponectin is an independent variable of serum PON1, which may contribute to the anti-atherosclerotic effect of adiponectin. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:363 / 367
页数:5
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