A Single Gene Target of an ETS-Family Transcription Factor Determines Neuronal CO2-Chemosensitivity

被引：29

作者：

Brandt, Julia P. ^{[1
,2
]}

Aziz-Zaman, Sonya ^{[1
,2
]}

Juozaityte, Vaida ^{[3
]}

Martinez-Velazquez, Luis A. ^{[1
,2
]}

Petersen, Jakob Gramstrup ^{[3
]}

Pocock, Roger ^{[3
]}

Ringstad, Niels ^{[1
,2
]}

机构：

[1] NYU, Helen L & Martin S Kimmel Ctr Biol & Med, Skirball Inst Biomol Med, Mol Neurobiol Program,Langone Med Ctr, New York, NY 10003 USA

[2] NYU, Langone Med Ctr, Dept Cell Biol, New York, NY USA

[3] Univ Copenhagen, BRIC, Copenhagen, Denmark

来源：

PLOS ONE | 2012年 / 7卷 / 03期

关键词：

CARBON-DIOXIDE AVOIDANCE; C-ELEGANS; GUANYLATE-CYCLASE; SENSING NEURONS; BRAIN-STEM; DOMAIN; OXYGEN; DIFFERENTIATION; TEMPERATURE; SEROTONIN;

D O I：

10.1371/journal.pone.0034014

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Many animals possess neurons specialized for the detection of carbon dioxide (CO2), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO2 is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO2. The ETS-5 transcription factor is necessary for the specification of CO2-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO2-detection and transforms neurons into CO2-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO2-sensing neurons in other phyla.

引用

页数：10

共 40 条

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