Total and Regional Brain Volumes in a Population-Based Normative Sample from 4 to 18 Years: The NIH MRI Study of Normal Brain Development

被引：267

作者：

Ball, William S. ^{[2
]}

Byars, Anna Weber ^{[2
]}

Schapiro, Mark ^{[2
]}

Bommer, Wendy ^{[2
]}

Carr, April ^{[2
]}

German, April ^{[2
]}

Dunn, Scott ^{[2
]}

Rivkin, Michael J. ^{[3
]}

Waber, Deborah ^{[3
]}

Mulkern, Robert ^{[3
]}

Vajapeyam, Sridhar ^{[3
]}

Chiverton, Abigail ^{[3
]}

Davis, Peter ^{[3
]}

Koo, Julie ^{[3
]}

Marmor, Jacki ^{[3
]}

Mrakotsky, Christine ^{[3
]}

Robertson, Richard ^{[3
]}

McAnulty, Gloria ^{[3
]}

Brandt, Michael E. ^{[4
]}

Fletcher, Jack M. ^{[4
]}

Kramer, Larry A. ^{[4
]}

Yang, Grace ^{[4
]}

McCormack, Cara ^{[4
]}

Hebert, Kathleen M. ^{[4
]}

Volero, Hilda ^{[4
]}

Botteron, Kelly ^{[5
]}

McKinstry, Robert C.

Warren, William ^{[5
]}

Nishino, Tomoyuki ^{[5
]}

Almli, C. Robert ^{[5
]}

Todd, Richard

Constantino, John

McCracken, James T. ^{[6
]}

Levitt, Jennifer ^{[6
]}

Alger, Jeffrey

O'Neill, Joseph ^{[6
]}

Toga, Arthur

Asarnow, Robert

Fadale, David

Heinichen, Laura

Ireland, Cedric

Wang, Dah-Jyuu ^{[7
]}

Moss, Edward ^{[7
]}

Zimmerman, Robert A. ^{[7
]}

Bintliff, Brooke ^{[7
]}

Bradford, Ruth ^{[7
]}

Newman, Janice ^{[7
]}

Evans, Alan C. ^{[8
]}

Arnaoutelis, Rozalia ^{[8
]}

Pike, G. Bruce ^{[8
]}

机构：

[1] McLean Hosp, Neurostat Lab, Belmont, MA 02478 USA

[2] Childrens Hosp Med Ctr Cincinnati, Cincinnati, OH USA

[3] Childrens Hosp Boston, Boston, MA USA

[4] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77225 USA

[5] Washington Univ, Clin Coordinating Ctr, St Louis, MO 63130 USA

[6] Univ Calif Los Angeles, Spect Proc Ctr, Los Angeles, CA 90024 USA

[7] Childrens Hosp Philadelphia, Philadelphia, PA USA

[8] McGill Univ, Data Coordinating Ctr, Montreal, PQ H3A 2T5, Canada

[9] Georgetown Univ, Washington, DC 20057 USA

[10] Harvard Univ, McLean Hosp, Cambridge, MA 02138 USA

[11] NIH, Diffus Tensor Proc Ctr, Bethesda, MD 20892 USA

来源：

CEREBRAL CORTEX | 2012年 / 22卷 / 01期

关键词：

adolescents; brain volumes; children; healthy; MRI; BODY-MASS INDEX; CEREBRAL ASYMMETRY; UNITED-STATES; MATTER VOLUME; PSYCHIATRIC-DISORDERS; SOCIOECONOMIC-STATUS; TEMPORALE ASYMMETRY; HEALTHY-INDIVIDUALS; SEXUAL-DIMORPHISM; HUMAN OBESITY;

D O I：

10.1093/cercor/bhr018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Using a population-based sampling strategy, the National Institutes of Health (NIH) Magnetic Resonance Imaging Study of Normal Brain Development compiled a longitudinal normative reference database of neuroimaging and correlated clinical/behavioral data from a demographically representative sample of healthy children and adolescents aged newborn through early adulthood. The present paper reports brain volume data for 325 children, ages 4.5-18 years, from the first cross-sectional time point. Measures included volumes of whole-brain gray matter (GM) and white matter (WM), left and right lateral ventricles, frontal, temporal, parietal and occipital lobe GM and WM, subcortical GM (thalamus, caudate, putamen, and globus pallidus), cerebellum, and brainstem. Associations with cross-sectional age, sex, family income, parental education, and body mass index (BMI) were evaluated. Key observations are: 1) age-related decreases in lobar GM most prominent in parietal and occipital cortex; 2) age-related increases in lobar WM, greatest in occipital, followed by the temporal lobe; 3) age-related trajectories predominantly curvilinear in females, but linear in males; and 4) small systematic associations of brain tissue volumes with BMI but not with IQ, family income, or parental education. These findings constitute a normative reference on regional brain volumes in children and adolescents.

引用

页码：1 / 12

页数：12

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