Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications

被引：131

作者：

Goncalves, Catarina ^{[1
]}

Pereira, Paula ^{[1
]}

Gama, Miguel ^{[1
]}

机构：

[1] Univ Minho, Ctr Biol Engn, IBB Inst Biotechnol & Bioengn, Braga, Portugal

来源：

MATERIALS | 2010年 / 3卷 / 02期

关键词：

polymer; delivery; targeting; self-assembly; drugs; NONVIRAL GENE DELIVERY; CHITOSAN-DNA NANOPARTICLES; POLY-L-LYSINE; BIODEGRADABLE POLYMERIC NANOPARTICLES; POLYELECTROLYTE COMPLEX MICELLES; NASAL ABSORPTION ENHANCEMENT; LOADED PLGA NANOPARTICLES; WATER-SOLUBLE CHITOSAN; IN-VITRO; DENDRITIC CELLS;

D O I：

10.3390/ma3021420

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hydrogel nanoparticles-also referred to as polymeric nanogels or macromolecular micelles-are emerging as promising drug carriers for therapeutic applications. These nanostructures hold versatility and properties suitable for the delivery of bioactive molecules, namely of biopharmaceuticals. This article reviews the latest developments in the use of self-assembled polymeric nanogels for drug delivery applications, including small molecular weight drugs, proteins, peptides, oligosaccharides, vaccines and nucleic acids. The materials and techniques used in the development of self-assembling nanogels are also described.

引用

页码：1420 / 1460

页数：41

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