Phytochemical and bioactivity studies on constituents of the leaves of Vitex quinata

被引：22

作者：

Deng, Ye ^{[1
]}

Chin, Young-Won ^{[1
]}

Chai, Hee-Byung ^{[1
]}

de Blanco, Esperanza Carcache ^{[1
,2
]}

Kardono, Leonardus B. S. ^{[3
]}

Riswan, Soedarsano ^{[4
]}

Soejarto, Djaja D. ^{[5
]}

Farnsworth, Norman R. ^{[5
]}

Kinghorn, A. Douglas ^{[1
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[2] Ohio State Univ, Coll Pharm, Div Pharm Practice & Adm, Columbus, OH 43210 USA

[3] Indonesian Inst Sci, Serpong 15310, Tangerang, Indonesia

[4] Indonesian Inst Sci, Biol Res Ctr, Herbarium Bogoriense, Bogor 16122, Indonesia

[5] Univ Illinois, Coll Pharm, Chicago, IL 60612 USA

来源：

PHYTOCHEMISTRY LETTERS | 2011年 / 4卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Cytotoxicity; (S)-5-Hydroxy-7,4 '-dimethoxyflavanone; Methyl 3,4,5-O-tricaffeoyl quinate; Methyl 10R-methoxy-12-oxo-9(13); 16E-Phytodienoate; NF-kappa B assay; 3,4,3 ',4 '-Tetrahydroxy-delta-truxinate; Vitex quinata; FLAVONOIDS;

D O I：

10.1016/j.phytol.2011.03.007

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A phytochemical investigation of the leaves of Vitex quinata (Lour.) F.N. Williams (Verbenaceae), guided by a cytotoxicity assay against the MCF-7 human breast cancer cell line, led to the isolation of a new delta-truxinate derivative (1) and a new phytonoic acid derivative (2), together with 12 known compounds. The structures of the new compounds were determined by spectroscopic methods as dimethyl 3,4,3 ',4 '-tetrahydroxy-delta-truxinate (1) and methyl 10R-methoxy-12-oxo-9(13), 16E-phytodienoate (2), respectively. In a cytotoxicity assay, (S)-5-hydroxy-7,4 '-dimethoxyflavanone (3) was found to be the sole active principle, with ED50 values of 1.1-6.7 mu M, respectively, when tested against a panel of three human cancer cells. Methyl 3,4,5-O-tricaffeoyl quinate (4) showed activity in an enzyme-based ELISA NF-kappa B p65 assay, with an ED50 value of 10.3 mu M. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：213 / 217

页数：5

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