Chlorodinitrophenylhydrazine, a useful crystalline agent for absolute configuration determination of various chiral ketones

被引：6

作者：

Kawai, Y ^{[1
]}

Hayashi, M

Tokitoh, N

机构：

[1] Nagahama Inst Biosci & Technol, Shiga 5260829, Japan

[2] Kyoto Univ, Chem Res Inst, Uji, Kyoto 6110011, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 21期

关键词：

phenylhydrazine chiral ketone; X-ray crystallography; absolute configuration;

D O I：

10.1016/j.tet.2005.03.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

For the determination of absolute configuration of various chiral ketones, we examined some hydrazines having a heavy atom as crystalline auxiliaries, and found that 2-chloro-4,6-dinitrophenylhydrazine is a useful crystalline agent for carbonyl compounds. Chiral hydrazones prepared from the hydrazine and various chiral ketones gave suitable single crystals for X-ray crystallographic analysis. The absolute configurations of the hydrazones were determined by X-ray crystallographic analysis using anomalous dispersion effect of the chlorine atom. The hydrazine is a useful crystalline agent for absolute configuration determination of various chiral ketones. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5049 / 5055

页数：7

共 44 条

[1] SIR97:: a new tool for crystal structure determination and refinement [J].