Predictors of high sensitivity C-reactive protein levels in patients with systemic lupus erythematosus

被引:18
作者
Lee, S-S [1 ,2 ]
Singh, S. [1 ]
Magder, L. S. [3 ]
Petri, M. [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Rheumatol, Baltimore, MD 21205 USA
[2] Chonnam Natl Univ, Sch Med, Dept Rheumatol, Kwangju, South Korea
[3] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Div Biostat & Bioinformat, Baltimore, MD 21201 USA
关键词
cardiovascular risk factors; C-reactive protein; systemic lupus erythematosus;
D O I
10.1177/0961203307085878
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite the increased prevalence of cardiovascular disease in patients with systemic lupus erythematosus (SLE), little is known about the role of high sensitivity C-reactive protein (hsCRP) or whether ethnicity, gender, anthropometric measures and treatment can alter hsCRP levels. We evaluated the effects of treatment and demographic, anthropometric and socio-economic variables on hsCRP levels in SLE. High sensitivity C-reactive protein levels were measured using an immunoturbidimetric assay in 610 patients from the Hopkins Lupus Cohort, who were followed-up regularly. In stepwise multiple regression analyses, body mass index (BMI) [odds ratio (OR) 1.72, 95% confidence interval (CI) 1.34-2.20, P < 0.001], African-American ethnicity (OR 1.97, 95% Cl 1.22-3.19, P < 0.01), education (OR 0.60, 95% Cl 0.42-0.86, P < 0.01), statin use (OR 0.38, 95% CI 0.18-0.82, P < 0.05), estrogen use (OR 3.65, 95% Cl 1.19-11.22, P < 0.05), SLE Disease Activity Index score (OR 1.76, 95% Cl 1.09-2.87, P < 0.05) and cumulative prednisone dose (OR 1.27, 95% Cl 1.01-1.60, P < 0.05) were significant predictors of hsCRP levels. These findings suggest that hsCRP levels should be adjusted for BMI, ethnicity, education level, disease activity and medications when conducting cardiovascular risk assessment in patients with lupus.
引用
收藏
页码:114 / 123
页数:10
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