Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe

被引：26

作者：

van Heyningen, C ^{[1
]}

机构：

[1] Univ Hosp, Clin Labs, Liverpool L9 7AL, Merseyside, England

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 2005年 / 42卷

关键词：

D O I：

10.1258/0004563054890105

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A case is presented of a patient who developed acute hepatitis during cholesterol-lowering treatment with atorvastatin and ezetimibe. Further investigations reveal a probable drug-induced autoimmune hepatitis, and ezetimibe is considered to be the most likely causal agent. This case is the first report of an autoimmune hepatitis associated with ezetimibe therapy.

引用

页码：402 / 404

页数：3

共 10 条

[1] Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption
Altmann, SW
Davis, HR
Zhu, LJ
Yao, XR
Hoos, LM
Tetzloff, G
Iyer, SPN
Maguire, M
Golovko, A
Zeng, M
Wang, LQ
Murgolo, N
Graziano, MP
[J]. SCIENCE, 2004, 303 (5661) : 1201 - 1204
[2] Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia - A prospective, randomized, double-blind trial
Ballantyne, CM
Houri, J
Notarbartolo, A
Melani, L
Lipka, LJ
Suresh, R
Sun, S
LeBeaut, AP
Sager, PT
Veltri, EP
[J]. CIRCULATION, 2003, 107 (19) : 2409 - 2415
[3] *BNF, 2004, EZETIMIBE SEP, P123
[4] Efficacy and safety of Ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia
Gagné, C
Bays, HÉ
Weiss, SR
Mata, P
Quinto, K
Melino, M
Cho, M
Musliner, TA
Gumbiner, B
[J]. AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (10) : 1084 - 1091
[5] Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia: A randomized, double-blind, placebo-controlled trial
Goldberg, AC
Sapre, A
Liu, J
Capece, R
Mitchel, YB
[J]. MAYO CLINIC PROCEEDINGS, 2004, 79 (05) : 620 - 629
[6] Drug-induced lupus-like syndrome associated with severe autoimmune hepatitis
Graziadei, IW
Obermoser, GE
Sepp, NT
Erhart, KH
Vogel, W
[J]. LUPUS, 2003, 12 (05) : 409 - 412
[7] Will the real cholesterol transporter please stand up
Klett, EL
Patel, SB
[J]. SCIENCE, 2004, 303 (5661) : 1149 - 1150
[8] Ezetimibe - A review of its metabolism, pharmacokinetics and drug interactions
Kosoglou, T
Statkevich, P
Johnson-Levonas, AO
Paolini, JF
Bergman, AJ
Alton, KB
[J]. CLINICAL PHARMACOKINETICS, 2005, 44 (05) : 467 - 494
[9] Target proteins in human autoimmunity: Cytochromes p450 and UDP-glucuronosyltransferases
Obermayer-Straub, P
Strassburg, CP
Manns, MP
[J]. CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2000, 14 (05): : 429 - 439
[10] Valois Maria, 2003, Can J Clin Pharmacol, V10, P59

← 1 →